Roma are again forced to make radical changes due to injuries and COVID, so Borja Mayoral leads the way against Gervinho’s Parma.
It kicks off at the Stadio Olimpico at 14.00 GMT.
The Giallorossi are technically unbeaten this season, as the only defeat was handed to Verona due to an irregularly-fielded player.
They have been decimated by COVID and injuries, missing Edin Dzeko, Marash Kumbulla, Federico Fazio, Davide Santon, Chris Smalling and Nicolò Zaniolo.
Bryan Cristante therefore steps in as a makeshift centre-back, with Pedro and Henrikh Mkhitaryan supporting Borja Mayoral.
Parma had at least seven COVID cases a few weeks ago, but the situation has now been completely resolved.
Coach Fabio Liverani has almost a full squad to count on at last, so Roberto Inglese is flanked by Juraj Kucka and ex-Roma star Gervinho, who is still going strong at 33.
Roma: Mirante; Mancini, Cristante, Ibanez; Karsdorp, Veretout, Villar, Spinazzola; Pedro, Mkhitaryan; Mayoral
Parma: Sepe; Osorio, Gagliolo, Bruno Alves, Pezzella; Grassi, Sohm, Cyprien; Gervinho, Inglese, Kucka