Milan give Jens Petter Hauge his first start in the supporting trio behind Ante Rebic, as they face Lille hat-trick hero Yusuf Yazici.
It kicks off at the Stade Pierre Mauroy at 17.55 GMT.
You can follow all the build-up and action as it happens from this game, Napoli-Rijeka and Cluj-Roma on the LIVEBLOG.
Milan give Jens Petter Hauge his first start in the supporting trio behind Ante Rebic, as they face Lille hat-trick hero Yusuf Yazici.
It kicks off at the Stade Pierre Mauroy at 17.55 GMT.
The Rossoneri suffered just one competitive defeat since the lockdown began in March and that was 3-0 to Lille at San Siro.
Stefano Pioli is still not on the touchline due to COVID, so Daniele Bonera again steps in after the 3-1 victory away to Napoli on Sunday evening.
Zlatan Ibrahimovic picked up a thigh strain during that match, with Rafael Leao and Alexis Saelemaekers also injured, so Norwegian teenager Hauge gets his first start upfront supporting Ante Rebic.
Lille again look to Yusuf Yazici, who scored a hat-trick at San Siro last time out, but Renato Sanches is injured in midfield.
Timothy Weah, son of Milan legend George, is on the bench.
Lille: Maignan; Pied, Fonte, Botman, Mandava; Araujo, Xeka, Andre, Bamba; Yazici, David
Lille bench: Karnezis, Chevalier, Tiago Djalo, Ikone, Burak Yilmaz, Lihadji, Weah, Soumare, Soumaoro, Niasse, Bradaric
Milan: G Donnarumma; Dalot, Kjaer, Gabbia, Theo Hernandez; Bennacer, Tonali; Castillejo, Calhanoglu, Hauge; Rebic
Milan bench: A Donnarumma, Calabria, Romagnoli, Conti, Kalulu, Brahim Diaz, Maldini, Colombo, Krunic, Duarte, Kessie
Ref: Pawson (ENG)