Roma improvise with Leonardo Spinazzola in a back three, Borja Mayoral and Carles Perez upfront as they visit CFR Cluj in the Europa League.
It kicks off in Romania at 20.00 GMT, you can follow the action as it happens from this game, Lille-Milan and Napoli-Rijeka in the LIVEBLOG.
Because of the crisis in defence, and their relatively comfortable current position in the Europa League group, Roma rotate the squad with numerous changes.
These include Bryan Cristante as a centre-back, but above all right-back Spinazzola going into the back three, an entirely new role for him.
Edin Dzeko is back after testing negative for COVID-19, but only on the bench, as Borja Mayoral again leads the way with support from Lorenzo Pellegrini and Carles Perez.
Among the absentees are Federico Fazio, Chris Smalling, Davide Santon, Roger Ibanez, Gianluca Mancini and Marash Kumbulla.
Cluj have problems too, missing Vinicius, Cestor, Deac, Hoban, Homrani and Youssef.
Cluj: Balgradean; Susic, Manea, Burca, Camora; Itu, Djokovic; Rondon, Paun, Pereira; Debeljuh
Cluj bench: Cheiches, Ciobotariu, Latovlevici, Haiduc, Chipciu, Vojtus, Joca, Carnat
Roma: Pau Lopez; Spinazzola, Cristante, Juan Jesus; Peres, Diawara, Villar, Calafiori; Perez, Pellegrini; Borja Mayoral
Roma bench: Berti, Mirante, Karsdorp, Dzeko, Pedro, Veretout, Ciervo, Milanese, Tripi, Mkhitaryan
Ref: Lechner (AUT)