Atalanta look to Papu Gomez, Duvan Zapata and Luis Muriel to break down Midtjylland and continue their march towards European glory.
La Dea are in a solid position for qualification to the final 16 for the second year in a row, having earned a 2-0 victory over Liverpool at Anfield.
They hope Liverpool will get back on track to beat Ajax today and push Atalanta even closer to the next phase.
Marco Sportiello returns in goal after Pierluigi Gollini suffered yet another knee injury, while Mario Pasalic and Mattia Caldara are sidelined, along with COVID cases Aleksei Miranchuk and Ruslan Malinovskyi.
Papu Gomez is ever-present, this time supporting Duvan Zapata and Luis Muriel, who were both benched last time in favour of Josip Ilicic.
Midtjylland are in their first ever Champions League campaign and have so far lost every match, including an opening 4-0 defeat on home turf to Atalanta.
Erik Sviatchenko is suspended, with Pione Sisto, Evander and Kristian Riss not fully fit.
Atalanta: Sportiello; Palomino, Romero, Djimsiti; Hateboer, Freuler, Pessina, Gosens; Gomez; Muriel, Duvan Zapata
Atalanta bench: Gelmi, Rossi, Toloi, De Roon, Piccini, Mojica, Depaoli, Ruggeri, Scalvini, Panada, Ilicic, Traore
Midtjylland: J Hansen; J Andersson, James, Scholz, Paulinho; Høegh; Dreyer, Anderson, Onyeka, Mabil; Kaba
Midtjylland bench: Thorsen, Ottesen, Cools, Kraev, Jensen, Vibe, Pfeiffer, Madsen, Dyhr, Isaksen, Sery, Schwartz,
Ref: Sidiropoulos (GRE)