Vedat Muriqi and Andreas Pereira lead the way for Lazio in the Coppa Italia against a revamped Parma, with Atalanta waiting in the quarter-final.
It kicks off at the Stadio Olimpico at 20.15 GMT.
The tie will be decided after 90 minutes, extra time or even a penalty shoot-out.
Lazio won this trophy in 2019 and go in without numerous top players, including Luis Alberto, who was rushed to hospital to have his appendix removed on Tuesday.
Luiz Felipe also had surgery today on his ankle, with Ciro Immobile rested and Lucas Leiva suspended.
Vedat Muriqi and Andreas Pereira lead the way for Lazio in the Coppa Italia against a revamped Parma, with Atalanta waiting in the quarter-final.
It kicks off at the Stadio Olimpico at 20.15 GMT.
The tie will be decided after 90 minutes, extra time or even a penalty shoot-out.
Lazio won this trophy in 2019 and go in without numerous top players, including Luis Alberto, who was rushed to hospital to have his appendix removed on Tuesday.
Luiz Felipe also had surgery today on his ankle, with Ciro Immobile rested and Lucas Leiva suspended.
Muriqi therefore leads the attack, seeking his first goal for the club, with Pereira in support.
Parma are still decimated by injuries, including Roberto Inglese, Andreas Cornelius, Gervinho, Juraj Kucka, Simone Iacoponi, Bruno Alves and Riccardo Gagliolo.
It is therefore a very young XI that takes to the pitch at the Stadio Olimpico this evening.
Lazio: Strakosha; Parolo, Hoedt, Acerbi; Lazzari, Milinkovic-Savic, Escalante, Akpa-Akpro, Fares; Pereira, Muriqi
Parma: Colombi; Busi, Kurtic, Dierckx, Ricci; Sohm, Cyprien, Dezi; Brunetta, Sprocati, Mihaila
Ref: Ayroldi