Diego Laxalt is pushing for a starting spot with Gonzalo Higuain for Milan, while Inter have two doubts in the Derby della Madonnina.
It kicks off at 19.30 UK time (18.30 GMT), you can follow all the action from today's Serie A games on the LIVEBLOG.
The two Coaches have found their preferred starting XIs this season and there are few real injury concerns going into this huge clash.
Diego Laxalt is pushing for a starting spot with Gonzalo Higuain for Milan, while Inter have two doubts in the Derby della Madonnina.
It kicks off at 19.30 UK time (18.30 GMT), you can follow all the action from today's Serie A games on the LIVEBLOG.
The two Coaches have found their preferred starting XIs this season and there are few real injury concerns going into this huge clash.
According to the latest reports, Matias Vecino and Sime Vrsaljko will be on the bench in favour of Roberto Gagliardini and Danilo D’Ambrosio.
Vecino returned from international duty with a slight injury and won’t be risked ahead of the Champions League encounter with Barcelona.
Mauro Icardi leads the way with support from Ivan Perisic, Radja Nainggolan and Matteo Politano probably preferred to Antonio Candreva.
Keita Balde Diao and Lautaro Martinez are ready to come off the bench and shake things up in the second half with their pace.
Milan’s main doubt is at right-back between Davide Calabria and Ignazio Abate, with the younger man tipped to get the nod from Gennaro Gattuso.
The Coach said in his Press conference yesterday that there were some ankle issues to look at and it’s reported those regard Jack Bonaventura and Franck Kessie, but neither should be at risk to start with Lucas Biglia.
Sky Sport Italia suggest Diego Laxalt is increasingly pushing for a spot in the starting XI, although it remains to be seen in what role.
Hakan Calhanoglu has been disappointing of late and Gattuso said he was struggling with “family issues,” so it could be completing the trident with Gonzalo Higuain and Suso.
Andrea Conti and Ivan Strinic are long-term absentees, with Mattia Caldara only fit for the bench.
Probable line-ups
Inter: Handanovic; D'Ambrosio, De Vrij, Skriniar, Asamoah; Gagliardini, Brozovic; Politano, Nainggolan, Perisic; Icardi
Inter bench: Padelli, Berni, Miranda, Ranocchia, Vrsaljko, Dalbert, Vecino, Borja Valero, Joao Mario, Candreva, Keita Balde, Lautaro Martinez
Milan: G Donnarumma; Calabria, Musacchio, Romagnoli, Rodriguez; Kessié, Biglia, Bonaventura; Suso, Higuain, Laxalt
Milan bench: Reina, A Donnarumma, Caldara, Zapata, Abate, Calhanoglu, Bakayoko, Bertolacci, Mauri, Borini, Castillejo, Cutrone
Ref: Guida