Napoli are forced to use Matteo Politano as a centre-forward and change tactics to a three-man defence, as they must overturn a 2-0 first leg defeat to Granada.
The second leg of the Europa League Round of 32 tie kicks off at the Stadio Diego Armando Maradona at 17.55 GMT.
You can follow all the build-up and action as it happens from this game, Milan-Red Star Belgrade and Roma-Braga on the LIVEBLOG.
Napoli are forced to use Matteo Politano as a centre-forward and change tactics to a three-man defence, as they must overturn a 2-0 first leg defeat to Granada.
The second leg of the Europa League Round of 32 tie kicks off at the Stadio Diego Armando Maradona at 17.55 GMT.
The Partenopei are in crisis, both in Serie A and in Europe, and much of that is due to the massive injury list that decimated the squad.
Politano and Lorenzo Insigne are the only forwards available, and even they are not 100 per cent fit.
Victor Osimhen needs absolute rest after he was knocked unconscious during the weekend defeat to Atalanta, while Hirving Lozano and Andrea Petagna are long-term absentees.
Kalidou Koulibaly is back in a new-look three-man defence, but Kostas Manolas, David Ospina, Diego Demme and Elseid Hysaj are still out of action.
Granada have been a revelation in Spain, promoted only last season, finishing seventh in La Liga to earn their first Europa League qualification and now on the verge of the last 16.
They won the first leg 2-0 at home, but make this trip without Quini, Luis Suarez and Neyder Lozano, while Luis Milla and Yangel Herrera are carrying knocks.
German Sanchez is suspended for the next league fixture, so he is given a start here.
Among the familiar faces are ex-Udinese player Darwin Machis, Chelsea loanee Kenedy and former Roma midfielder Maxime Gonalons.
Napoli: Meret; Rrahmani, Koulibaly, Maksimovic; Di Lorenzo, Fabian Ruiz, Bakayoko, Elmas; Zielinski; Politano, Insigne
Napoli bench: Contini, Idasiak, Zedadka, Mario Rui, Mertens, Ghoulam, Costanzo, D’Agostino, Cioffi, Labriola, Lobotka
Granada: Rui Silva; Foulquier, German, Duarte, Neva; Montoro, Brice; Machis, Gonalons, Kenedy; Molina
Granada bench: Banacloche, Fabrega, Neuhen Perez, Soldado, Antonio Puertas, Victor Diaz, Vallejo, Herrera, Aranda, Isma Ruiz, Torrente Navarro
Ref: Siebert (GER)