Alvaro Morata, Cristiano Ronaldo and Federico Chiesa lead the way for Juventus, as they must overturn the 2-1 first leg Champions League defeat to FC Porto.
It kicks off at the Allianz Juventus Stadium in Turin at 20.00 GMT.
You can follow all the build-up and action as it happens on the LIVEBLOG.
The first leg ended 2-1 for Porto, with Federico Chiesa’s late away goal potentially decisive in this fixture.
Alvaro Morata, Cristiano Ronaldo and Federico Chiesa lead the way for Juventus, as they must overturn the 2-1 first leg Champions League defeat to FC Porto.
It kicks off at the Allianz Juventus Stadium in Turin at 20.00 GMT.
You can follow all the build-up and action as it happens on the LIVEBLOG.
The first leg ended 2-1 for Porto, with Federico Chiesa’s late away goal potentially decisive in this fixture.
There are significant changes to the side that beat Lazio 2-1 on Saturday, because Danilo is suspended, although Rodrigo Bentancur is still out with COVID and Paulo Dybala has that long-running knee injury.
Leonardo Bonucci is back in the starting XI, but Matthijs de Ligt is not at 100 per cent, so Merih Demiral gets the nod rather than Giorgio Chiellini.
The choice in midfield was between Aaron Ramsey and Weston McKennie, while Arthur returns from his muscular issue.
Alvaro Morata partners Cristiano Ronaldo, with Chiesa taking the wide left role.
CR7 is hoping to add to his remarkable record of 135 goals in 175 Champions League games, including 67 strikes in 81 knockout fixtures.
FC Porto are coached by former Lazio, Parma and Inter man Sergio Conceicao, so he is no stranger to Italian football.
Veteran defender Pepe was a major doubt, but he is in the starting XI, meaning it is exactly the same line-up that beat Juventus 2-1.
Because of that result, a 1-0 Juventus win would be enough to qualify on the away goals rule.
Porto have faced the Bianconeri six times in Europe, managing one victory, a draw and four defeats.
Curiously, the Portuguese giants have been knocked out in each of the last three Champions League ties when winning the first leg, eliminated by Arsenal in 2009-10, Malaga in 2012-13 and Bayern Munich in 2014-15.
Juventus: Szczesny; Cuadrado, Demiral, Bonucci, Alex Sandro; Ramsey, Arthur, Rabiot, Chiesa; Morata, Ronaldo
Juventus bench: Pinsoglio, Buffon, Chiellini, De Ligt, McKennie, Bernardeschi, Di Pardo, Dragusin, Frabotta, Fagioli,, Kulusevski
Porto: Marchesin; Manafá, Mbemba, Pepe, Zaidu; Corona, Uribe, Sergio Oliveira, Otavio; Marega, Taremi
Porto bench: Diogo Costa, Diogo Leite, Loum, Luis Diaz, Grujic, Felipe Anderson, Toni Martinez, Evanilson, Nanu, Sarr, Fabio Vieira, Francisco Conceicao
Ref: Kuipers (NED)