Inter start Stefano Sensi and Alexis Sanchez, as they host Radja Nainggolan and Diego Godin’s desperate Cagliari.
It kicks off at San Siro at 11.30 UK time (10.30 GMT).
The Nerazzurri need a win to keep their lead at the top of the table at 11 points, because Milan beat Parma 3-1 yesterday.
Marcelo Brozovic and Alessandro Bastoni return from suspension but Nicolò Barella sits out a ban against his hometown club, so Sensi gets the nod rather than Roberto Gagliardini, Matias Vecino or not 100 per cent fit Arturo Vidal.
Lautaro Martinez is rested, so Alexis Sanchez starts with Romelu Lukaku.
Cagliari are increasingly desperate, because with Torino’s victory away to Udinese last night, they have fallen five points adrift of the safety zone.
Coach Leonardo Semplici had an immediate boost when replacing Eusebio Di Francesco, but that effect seems to have worn off rapidly.
Injuries are also an issue, with Alessandro Deiola, Luca Ceppitelli, Riccardo Sottil and Marko Rog out of action, and above all goalkeeper Alessio Cragno caught COVID-19 in the Italy international group outbreak.
That means 24-year-old Guglielmo Vicario makes his Serie A debut.
It’s a special game for Godin and Nainggolan, who are both on loan from Inter, while Leonardo Pavoletti partners Joao Pedro.
Inter: Handanovic; Skriniar, De Vrij, A Bastoni; Darmian, Sensi, Brozovic, Eriksen, Young; Alexis Sanchez, Lukaku
Inter bench: Padelli, Radu, Hakimi, Gagliardini, Vecino, Lautaro Martinez, Ranocchia, Perisic, D’Ambrosio, Pinamonti
Cagliari: Vicario; Rugani, Godin, Carboni; Zappa, Marin, Duncan, Nainggolan, Nandez; Joao Pedro, Pavoletti
Cagliari bench: Aresti, Ciocci, Tripaldelli, Simeone, Klavan, Calabresi, Asamoah, Pereiro, Lykogiannis, Cerri, Walukiewicz