Juventus will start Paulo Dybala in Cristiano Ronaldo’s absence, while Atalanta must decide whether to field both Colombians Duvan Zapata and Luis Muriel.
It kicks off on Sunday at 14.00 UK time (13.00 GMT).
Both teams are forced into changes during this showdown for third place, as only one point separates them going into the weekend.
The big news is that Ronaldo isn’t even in the squad travelling to Bergamo, as he has a muscular issue and remains in doubt for the midweek round with Parma too.
Coach Andrea Pirlo confirmed Dybala will start, presumably with Alvaro Morata and Federico Chiesa.
Federico Bernardeschi is still out of action with COVID, although Leonardo Bonucci has now recovered, but Giorgio Chiellini is still expected to start.
A change could see Juan Cuadrado pushed into a more advanced right winger role in the 4-4-2 formation, providing more defensive solidity against Robin Gosens rather than Dejan Kulusevski or Weston McKennie.
Atalanta have Cristian Romero – who is on loan from Juventus – suspended and Hans Hateboer still out injured, but Matteo Pessina returns after his COVID bout.
Several options are open to Gian Piero Gasperini, including whether to stick with his recent four-man defence using Gosens as a left-back or returning to the old 3-4-1-2 formation.
Pessina might not be thrown straight into the starting XI, especially with Ruslan Malinovskyi in such excellent form, providing five assists in his last three games.
It remains to be seen also if Luis Muriel and Duvan Zapata will start together or one of the Colombians reserved for the second half against tired legs.
Josip Ilicic is another wild card, but unlikely to start, considering his recent form.
Atalanta (4-2-3-1): Gollini; Toloi, Palomino, Djimsiti, Gosens; De Roon, Freuler; Malinovskyi, Pessina, Muriel; Duvan Zapata
Juventus (4-4-2): Szczesny; Danilo, De Ligt, Chiellini, Alex Sandro; Cuadrado, Bentancur, Rabiot, Chiesa; Dybala, Morata