Rafael Leao and Ante Rebic lead the Milan attack with Zlatan Ibrahimovic suspended, while Genoa look to Gianluca Scamacca and Mattia Destro.
It kicks off at San Siro at 11.30 UK time (10.30 GMT).
Ibrahimovic sits out a ban after his red card for saying something the referee did not appreciate during the 3-1 win at Parma last week.
It means Leao is chosen to lead the attack, as Mario Mandzukic is in the squad, but still not fully fit after a long injury lay-off.
Mandzukic hit the headlines this week, as he donated his March salary to charity because he had been unable to play during that period.
Ante Rebic, Hakan Calhanoglu and Alexis Saelemaekers complete the trio in support, while Davide Calabria is still out of action and Alessio Romagnoli only fit for the bench.
Genoa are not quite safe from the threat of relegation yet, so every point remains precious for them.
Captain Domenico Criscito is suspended, with Luca Pellegrini injured, so Edoardo Goldaniga and Ivan Radovanovic step into defence.
Kevin Strootman returns from his ban, supporting Destro and Italy Under-21 international Scamacca, who is a known Rossoneri transfer target.
Genoa are the only Serie A side, along with Atalanta, that Stefano Pioli has been unable to beat on the Milan bench, managing one loss and this season’s 2-2 draw.
Milan: G Donnarumma; Kalulu, Kjaer, Tomori, Theo Hernandez; Bennacer, Kessie; Saelemaekers, Calhanoglu, Rebic; Leao
Genoa: Perin; Goldaniga, Radovanovic, Masiello; Ghiglione, Badelj, Zajc, Strootman, Cassata; Destro, Scamacca