Lazio have to reshuffle their defence against a Genoa side desperate for points to break clear of the drop zone.
It kicks off at 11.30 UK time (10.30 GMT).
Simone Inzaghi’s men have won 10 consecutive Serie A home matches, so this could be a new all-time club record of 11.
However, Francesco Acerbi is suspended, with Luiz Felipe, Gonzalo Escalante and Felipe Caicedo injured, so Wesley Hoedt steps into the back three, with Adam Marusic again used in defence.
Ciro Immobile is partnered again by Joaquin Correa, with Luis Alberto and Sergej Milinkovic-Savic in support.
Genoa have former Lazio star Goran Pandev suspended, with Domenico Criscito and Luca Pellegrini on the treatment table.
Eldor Shomurodov gets the nod with Mattia Destro, and ex-Roma midfielder Kevin Strootman is ready for a derby atmosphere.
Lazio: Reina; Marusic, Hoedt, Radu; Lazzari, Milinkovic-Savic, Leiva, Luis Alberto, Lulic; Correa, Immobile
Genoa: Perin; Biraschi, Radovanovic, Masiello; Goldaniga, Strootman, Badelj, Zajc, Zappacosta; Destro, Shomurodov