Roma are decimated for this trip to Sampdoria and still reeling from the 6-2 Europa League semi-final defeat to Manchester United, but use Edin Dzeko and Borja Mayoral together.
It kicks off at 19.45 UK time (18.45 GMT).
The wheels have well and truly come off Roma’s campaign, with coach Paulo Fonseca practically admitting he will not be here next year.
That decision had been made even before the humiliating 6-2 defeat to Manchester United, which came despite them leading 2-1 at half-time.
Leonardo Spinazzola, Pau Lopez and Jordan Veretout all limped off at Old Trafford in the opening 37 minutes, with Amadou Diawara and Carles Perez also picking up injuries on Thursday.
Add to the existing absentees Pedro, Riccardo Calafiori, Stephan El Shaarawy and Nicolò Zaniolo, and there are precious few alternatives to choose from.
Even Lorenzo Pellegrini has been given the day off, as he became a father to little Thomas today.
Fonseca therefore does something he said did not work, using Edin Dzeko and Borja Mayoral together, with Henrikh Mkhitaryan in support.
He even gives third choice goalkeeper Daniel Fuzato a chance to shine.
Sampdoria are comfortably mid-table and feeling no pressure, with only Ernesto Torregrossa on the treatment table.
Sampdoria: Audero; Bereszynski, Tonelli, Colley, Augello; Damsgaard, Thorsby, Adrien Silva, Jankto; Verre; Gabbiadini
Roma: Fuzato; Mancini, Smalling, Kumbulla; Peres, Villar, Cristante, Santon; Mkhitaryan; Dzeko, Mayoral