Inter have revamped again with a Rodrigo Palacio-Diego Milito-Antonio Cassano trident attack against Catania.
The Nerazzurri need a win to keep up with Lazio in third place and hope to continue the enthusiasm generated by their derby victory before the break for international duty.
Wesley Sneijder, Dejan Stankovic, Cristian Chivu and MacDonald Mariga are still injured, while Yuto Nagatomo is suspended following his red card against Milan.
There were some doubts over who would start in attack, but Andrea Stramaccioni has picked a trident with Palacio stepping in to replace Philippe Coutinho.
Andrea Ranocchia passed a last-minute fitness test to take his place in defence.
Catania have never won at San Siro, but fumbled a 2-0 lead here last season to draw 2-2 and are one of the surprise packages of this campaign.
Giuseppe Bellusci, Augustyn and Sciacca are unavailable for Coach Rolando Maran, but Nicola Legrottaglie has shaken off an injury to start.
Inter: Handanovic; Ranocchia, Samuel, Juan Jesus; Obi, Mudingayi, Cambiasso, Zanetti; Cassano, Milito, Palacio
Inter bench:Cincilla, Belec, Silvestre, Mbaye, Duncan, Pereira, Guarin, Gargano, Coutinho, Jonathan, Alvarez, Livaja
Catania: Andujar; Álvarez, Legrottaglie, Spolli, Marchese; Izco, Lodi, Almiron; Barrientos, Bergessio, Gomez
Catania bench:Frison, Messina, Rolín, Potenza, Capuano, Biagianti, Salifu, Ricchiuti, Morimoto, Castro, Doukara
See the latest Serie A predictions and betting tips with Eurotips.co.uk