Inter are completely revamped in an emergency situation as they face Tottenham Hotspur and Gareth Bale at White Hart Lane.
The first leg of their Europa League Round of 16 kicks off at White Hart Lane at 20.05 GMT.
The Nerazzurri are reduced to an absolute skeleton team, as Diego Milito, Walter Samuel, Yuto Nagatomo, Zdravko Kuzmanovic, Matias Silvestre, Ezequiel Schelotto, Tommaso Rocchi, Dejan Stankovic, Joel Obi, Gaby Mudingayi and Luca Castellazzi are all unavailable due to injury or being cup-tied.
Andrea Ranocchia, Fredy Guarin and Esteban Cambiasso needed last-minute fitness tests in London, but midfielder Guarin was only fit for the bench.
Coach Andrea Stramaccioni is left with precious few options to choose from, so 18-year-old January signing Mateo Kovacic is given a crucial role supporting surprise lone striker Antonio Cassano.
It is a return to the line-up for Cassano, who had been dropped for Sunday’s 3-2 win away to Catania after a locker room bust-up with Stramaccioni.
This means that Rodrigo Palacio is left on the bench, probably to preserve him for Serie A.
Spurs can count on Welsh winger Bale, who famously scored a hat-trick at San Siro in the Champions League in 2010.
Emmanuel Adebayor has a knee injury, joining the injured Younes Kaboul, Sandro, Tom Huddlestone and Clint Dempsey.
Mousa Dembele is able to start despite picking up a knock against Arsenal on Sunday.
Tottenham: Friedel; Walker, Vertonghen, Gallas, Assou-Ekotto; Dembele, Parker; Lennon, Sigurdsson, Bale; Defoe
Tottenham bench: Lloris, Caulker, Naughton, Dawson, Livermore, Carroll, Holtby
Inter: Handanovic; Zanetti, Ranocchia, Chivu, Juan Jesus; Gargano, Cambiasso; Alvarez, Kovacic, Alvaro Pereira; Cassano
Inter bench: Belec, Mbaye, Jonathan, Guarin, Benassi, Pasa, Palacio