Catania and Udinese go head-to-head for a place in Europe, but the Friulani are decimated by bans and injuries.
Serie A Week 29 kicks off at 17.00 GMT at the Stadio Massimino, click here for a match preview.
Only one point separates these sides going into the game, as Catania are in eighth place and Udinese ninth.
The Sicilians welcome back Nicola Legrottaglie from suspension, but Nicolas Spolli begins his two-match ban for insulting the referee.
Gonzalo Bergessio has shaken off his injury, but is only fit for the bench.
Udinese have huge problems in Catania, as they are without talismanic captain Antonio Di Natale due to a muscular strain.
Also on the treatment table are Dusan Basta, Giampiero Pinzi, Andrea Lazzari and Giovanni Pasquale.
There are also numerous suspension issues to contend with, as Maurizio Domizzi, Maicosuel and Thomas Heurtaux are all banned.
Luis Muriel has to take control of the attack with Roberto Pereyra in support.
Catania: Andujar; Alvarez, Bellusci, Legrottaglie, Marchese; Lodi, Almiron; Izco, Castro, Barrientos; Gomez
Catania bench: Frison, Terracciano, Potenza, Rolin, Biagianti, Ricchiuti, Salifu, Bergessio, Doukara, Cani, Keko, Petkovic
Udinese: Brkic; Benatia, Danilo, Angella; Faraoni, Badu, Allan, Merkel, Gabriel Silva; Pereyra; Muriel
Udinese bench: Padelli, Pawlowski, Berra, Campos Toro, Rodriguez, Marsura, Ranegie, Zielinski
See the latest Serie A predictions and betting tips with Eurotips.co.uk