Genoa and Livorno are both riding on a wave of enthusiasm, but who will fall off first?
Marassi hosts the evening kick-off in Serie A at 19.45 UK time (18.45 GMT), click here for a match preview.
Fabio Liverani and Genoa have had a great week after thrashing arch rivals Sampdoria 3-0 for the biggest Derby della Lanterna away victory ever.
Juraj Kucka has joined Luca Antonelli on the injury list, so derby goalscorer Luca Antonelli again starts in defence.
Livorno have done very well for a newly-promoted side, notching up two consecutive victories.
Ruben Botta is still unavailable for Coach Davide Nicola, who again looks to his sparkling front two of Innocent Emeghara and Paulinho. Emerson looked set to recover, but hasn't made it.
It’s a special match for Nicola, who played for Genoa from 1995-2002.
Livorno are unbeaten in Genoa since a 3-1 Serie B result in April 2003 and scored in their last six visits.
Genoa: Perin; Gamberini, Portanova, Manfredini; Vrsaljko, Biondini, Lodi, Matuzalem, Antonini; Calaiò, Gilardino
Livorno: Bardi; Coda, Rinaudo, Ceccherini; Schiattarella, Luci, Mbaye, Biagianti, Greco; Emeghara, Paulinho
See the latest Serie A predictions and betting tips with Eurotips.co.uk