Lazio are in desperate need of a boost after two humiliating defeats and host giant-killers Udinese.
It kicks off at the Stadio Olimpico in Rome at 17.00 UK time (16.00 GMT), click here for a match preview.
The Aquile finished third in Serie A last season and reached the Coppa Italia Final, but so far this campaign has been disastrous.
They lost the Italian Super Cup to Juventus in Shanghai, crashed out of the Champions League play-offs with a 3-0 defeat at Bayer Leverkusen and were crushed 4-0 by Chievo in Serie A.
Alessandro Matri was expected to get his first start for Lazio after arriving on loan from Milan on deadline day, but instead Keita Balde Diao is picked while veteran Stefano Mauri also returns to the XI.
Mauri’s contract had been allowed to expire in June, but he was signed on again in August after learning he wouldn’t face trial for match-fixing allegations.
Stefan de Vrij, Lucas Biglia, Miroslav Klose and Filip Djordjevic are all on the treatment table, but Federico Marchetti returns precisely one month since cracking his ribs.
Danilo Cataldi is chosen ahead of Sergej Milinkovic-Savic to replace Biglia, while Wesley Hoedt is given his debut in defence.
Udinese stunned Juventus 1-0 in Turin for the opening game, but were then unlucky to lose against Palermo on home turf.
Antonio Di Natale is not 100 per cent fit due to a back problem, while Silvan Widmer and Guilherme miss out.
That means Duvan Zapata partners Cyril Thereau.
Lazio: Marchetti; Basta, Mauricio, Hoedt, Radu; Cataldi, Parolo; Lulic, Candreva, Mauri; Keita
Lazio bench: Berisha, Guerrieri, Konko, Gentiletti, Braafheid, Morrison, Onazi, Milinkovic-Savic, Oikonomidis, Matri, Felipe Anderson, Kishna
Udinese: Karnezis; Heurtaux, Danilo, Piris; Edenilson, Kone, Iturre, Fernandes, Adnan; Zapata, Thereau
Udinese bench: Romo, Wague, Heurtaux, Felipe, Domizzi, Insua, Badu, Pasquale, Merkel, Marquinho, Di Natale, Aguirre
See the latest Serie A predictions and betting tips with Eurotips.co.uk