Milan and Napoli go head-to-head at San Siro with strong strike forces and struggling defences.
It kicks off at 19.45 UK time (18.45 GMT), follow all the action from this and Fiorentina-Atalanta on our LIVEBLOG.
The Rossoneri have a decent home record, but need a boost after last week’s 1-0 defeat to Genoa.
Alessio Romagnoli was sent off in that game and is therefore suspended, joining injured Mario Balotelli, Jeremy Menez, Philippe Mexes, M’Baye Niang and Ignazio Abate in the stands.
Carlos Bacca and Luiz Adriano are reunited in attack with support from Jack Bonaventura, while Rodrigo Ely steps into the back four.
Napoli have been on sparkling form recently, smashing Lazio and Club Brugge 5-0, then beating Legia Warsaw 2-0 in the Europa League on Thursday.
Gonzalo Higuain scored a sensational solo goal in Poland and he leads the way with Lorenzo Insigne, Jose Callejon and Marek Hamsik.
Pepe Reina passed a late fitness test for muscular problems and returns to the goal, but Milan-owned Gabriel is ready to step in from the bench if needed.
Once again, Jorginho is given the nod rather than Mirko Valdifiori in midfield.
Milan: Diego Lopez; De Sciglio, Zapata, Ely, Antonelli; Kucka, Montolivo, Bertolacci; Bonaventura; Luiz Adriano, Bacca
Milan bench: Abbiati, Donnarumma, Alex, Calabria, De Jong, Jose Mauri, Nocerino, Poli, Suso, Cerci, Honda
Napoli: Reina; Hysaj, Albiol, Koulibaly, Ghoulam; Allan, Jorginho, Hamsik; Callejon, Higuain, Insigne
Napoli bench: Gabriel, Rafael, Strinic, Chiriches, Maggio, Henrique, David Lopez, El Kaddouri, Valdifiori, Chalobah, Mertens, Gabbiadini
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