Juventus can join Inter in second place with a ninth consecutive victory, but face on-form Sampdoria and Antonio Cassano.
It kicks off at Marassi at 19.45 GMT, click here for a match preview.
Follow the action from all seven of today’s Serie A games on our LIVEBLOG and give your views.
Napoli are the Winter Champions following a 5-1 win at Frosinone, taking advantage of shock home defeats for Inter and Fiorentina.
That means with a win Juve would go into joint second place with Inter, just two points off the top spot.
It’d be a remarkable achievement considering the disastrous start to the season and represent a ninth consecutive Serie A victory.
However, Samp have also won two on the bounce and are fresh from the Derby della Lanterna success on Tuesday night.
Cassano was inspirational with a series of assists and he again starts with Eder and Carlos Carbonero, so Luis Muriel is benched.
Lorenzo De Silvestri and Matias Silvestre are out injured, but Coach Vincenzo Montella sticks by the men who won the Derby della Lanterna.
Ricky Alvarez signed this week, but is not available because the international transfer hasn't come through.
Juventus need to make changes too, as Claudio Marchisio sits out a ban with Andrea Barzagli, Mario Mandzukic, Mario Lemina and Roberto Pereyra injured.
Hernanes therefore gets a rare start in midfield, while Alvaro Morata gets the nod ahead of Simone Zaza to partner Paulo Dybala.
Daniele Rugani is finally given his first Serie A start for Juve, sending Martin Caceres to the bench.
Sampdoria: Viviano; Cassani, Moisander, Zukanovic, Regini; Soriano, Fernando, Barreto; Carbonero, Cassano, Eder
Sampdoria bench: Puggioni, Pedro Pereira, Krsticic, Coda, Rodriguez, Puggioni, Muriel, Correa, Palombo, Christodoulopoulos, Ivan, Brignoli
Juventus: Buffon; Rugani, Bonucci, Chiellini; Lichtsteiner, Khedira, Hernanes, Pogba, Evra; Morata, Dybala
Juventus bench: Neto, Audero, Caceres, Alex Sandro, Padoin, Sturaro, Asamoah, Vitale, Cuadrado, Zaza
Watch Serie A live in the UK on Premier Sports for just £11.99 per month including live LaLiga, Eredivisie, Scottish Cup Football and more. Visit: https://subscribe.premiersports.tv/