Inter shelve the squad rotation and try to end their crisis with Mauro Icardi and returning Marcelo Brozovic against Southampton.
It kicks off at 18.00 UK time (17.00 GMT) at San Siro, follow all four Italian sides in action on our LIVEBLOG.
The Nerazzurri are in absolute crisis, losing both Europa League games so far against Hapoel Beer-Sheva and Sparta Prague, while they were beaten 2-1 at home by newly-promoted Cagliari in Ser
Inter shelve the squad rotation and try to end their crisis with Mauro Icardi and returning Marcelo Brozovic against Southampton.
It kicks off at 18.00 UK time (17.00 GMT) at San Siro, follow all four Italian sides in action on our LIVEBLOG.
The Nerazzurri are in absolute crisis, losing both Europa League games so far against Hapoel Beer-Sheva and Sparta Prague, while they were beaten 2-1 at home by newly-promoted Cagliari in Serie A on Sunday.
That match was overshadowed by the controversy surrounding captain Icardi, whose autobiography offended a section of the ultras and they have declared he is “dead” to them.
It remains to be seen what the atmosphere will be like this evening, but it’s definitely not the best way to go into a must-win clash.
Inter run the real risk of going out of the Europa League in the group phase and Coach Frank de Boer’s job is on the line with a series of poor results.
Some changes are foisted upon him, as due to Financial Fair Play considerations Inter don’t have Joao Mario, Geoffrey Kondogbia, Gabigol or Stevan Jovetic in the Europa League squad.
Icardi is usually rested, but he starts today with the returning Brozovic, a Croatia international midfielder who had been frozen out for over a month due to unprofessional behaviour.
Eder and Antonio Candreva complete the trident attack, resting Argentina international Ever Banega.
Andrea Ranocchia is suspended following his red card in Prague, while Felipe Melo is injured.
Southampton are missing Ryan Bertrand, Nathan Redmond and Cedric for this trip to the Stadio Giuseppe Meazza.
Ireland international Shane Long leads the attack with support from Jay Rodriguez and Dusan Tadic.
Club record signing Sofiane Boufal is available for the first time since arriving over the summer.
The Saints have won only one of their last seven European away fixtures, losing three. It is their first ever meeting with Inter.
Claude Puel’s side won the first game 3-0 at home to Sparta Prague and drew 0-0 in Israel.
Inter: Handanovic Nagatomo, Miranda, Murillo, Santon; Gnoukouri, Medel, Brozovic; Candreva, Icardi, Eder
Inter bench: Carrizo, Yao, Ansaldi, D’Ambrosio, Banega, Perisic, Palacio
Southampton: Forster; Martina, Yoshida, Van Dijk, McQueen; Hojberg, Romeu, Ward-Prowse; Tadic; Long, Rodriguez
Southampton bench: McCarthy, Fonte, Stephens, Clasie, Boufal, Austin, Davis
Ref: Mazeika (LTU)