Giacomo Bonaventura and Carlos Bacca are still not back in full Milan training, so are huge doubts to feature against Roma.
It kicks off at the Stadio Olimpico on Monday at 20.00 GMT, click here for a match preview.
The Rossoneri are certainly without suspended Juraj Kucka, while Davide Calabria and Riccardo Montolivo are injured.
Bonaventura and Bacca were hoping to make it into the squad, but Sky Sport Italia note this is increasingly unlikely.
Both the midfielder and forward are only training in the gym today and didn’t step on to the pitch at all.
It seems therefore that Andrea Bertolacci and Jose Ernesto Sosa are challenging for the midfield role in Bonaventura’s absence.
When it comes to the front line, Gianluca Lapadula’s excellent recent form had seen him overtake Bacca even without the injury problems.