Gareth Bale is on the bench, but Kevin-Prince Boateng starts with Alexandre Pato, Robinho, Clarence Seedorf and Zlatan Ibrahimovic at White Hart Lane.
Milan need to overturn a 1-0 first leg defeat at San Siro, but have to completely revamp their midfield against Tottenham.
Gennaro Gattuso is suspended following his fracas with Joe Jordan, joining the cup-tied Antonio Cassano, Mark Van Bommel and Urby Emanuelson.
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