Inter make changes including Davide Frattesi against his old club, as Sassuolo are desperate to avoid relegation with Andrea Pinamonti.
It kicks off at the Mapei Stadium at 19.45 UK time (18.45 GMT).
You can follow all the build-up and action as it happens from this game and Monza-Lazio on the LIVEBLOG.
The Scudetto celebrations are still going, so Simone Inzaghi makes changes to give everyone some playing time, including Alexis Sanchez, Emil Audero, Kristjan Asllani, Carlos Augusto and former Sassuolo midfielder Frattesi.
Sassuolo have to change too, but these are forced upon them, as Ruan Tressoldi is suspended with Samu Castillejo, Gregoire Defrel and Domenico Berardi injured.
Mattia Viti and Kristian Thorstvedt are not fully fit either, but Sassuolo are truly desperate in penultimate place, coming off a 5-1 defeat to Fiorentina.
Yet Sassuolo are the only side in Serie A to have beaten Inter this season, 2-1 at San Siro back on September 27.
Armand Laurienté returns from his ban with ex-Inter youth product Andrea Pinamonti upfront.
Sassuolo vs. Inter line-ups
Sassuolo: Consigli; Erlic, Ferrari, Kumbulla; Toljan, Lipani, Matheus Henrique, Thorstvedt, Doig; Laurienté, Pinamonti
Inter: Audero; Pavard, de Vrij, Bastoni; Dumfries, Frattesi, Asllani, Mkhitaryan, Carlos Augusto; Lautaro Martinez, Sanchez
