Pepe Reina is concerned by Sampdoria’s recent form, but Milan “realise it’s decided today and will give our all” in the Coppa Italia.
The Round of 16 clash kicks off at Marassi at 17.00 GMT, click here for the line-ups.
The winners will go through to face Napoli or Sassuolo in the quarter-final.
“It’s a difficult game, it’s a one-off, Sampdoria are doing well this season and have a set playing style that they know off by heart,” Reina told Rai Sport.
“We too are confident in our approach, we realise it’s decided today and will give our all.”